• United Kingdom, Uk
  • Save Job
  • 2 - 3 Years
  • Posted : above 1 month

Job Description:

At AstraZeneca we win through science, its at the heart of our every success We continuously craft partnerships to expand our science to help pursue world-class medicines in new ways, combining our peoples exceptional skills with those of people from all over the globe We have a great opportunity for you to play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients lives

Spirogen sits within the AstraZeneca Science Units and is highly innovative The team has developed a potent and flexible class of ADC (Antibody Drug Conjugate) payloads based on their proprietary PBD (pyrrolobenzodiazepine) platform technology, with marked improvements in terms of activity, ease of manufacture and therapeutic index

Our science lives beyond our labs Our global perspective means AstraZeneca use talent and expertise from all over the world to make our medicines a success With an exciting research pipeline, this is a great time to develop your career with Spirogen Are you ready for a new challenge and keen to join as Head of Analytical group You will be based in the London Spirogen offices, reporting into the Chief Scientific Officer

If youre encouraged to work for a world premier biopharmaceutical company delivering life-changing products join us

Your responsibilities will include You will lead and develop a team of analytical scientists, and you take line-management responsibility for the team
You plan, prioritise and schedule the teams activities, ensuring appropriate studies are delivered on time
You will manage the day-to-day running of a mass spectrometry laboratory
You display scientific leadership in developing the analytical sciences team and in your contributions to the companys Antibody-Drug Conjugate R&D activities Use sound scientific judgement in communicating scientific recommendations to key business partners
You actively build partnerships and represent analytical sciences on project teams across the company, and with external organizations
Support ADC Research activities with analytical studies as required These include hyphenated (RP-, IEX-, HIC-, and SEC-) LCMS techniques, small molecule MS, native protein MS, peptide mapping and targeted proteomics
Drive the development, validation and implementation of assays for the quantitation and/or characterisation of both the small molecule and protein components of ADCs in various matrices (eg tissue, plasma, blood, buffer), especially as applied to PK analysis

Essential requirements You have completed a PhD in a relevant Analytical field and Post-Doctoral or equivalent industrial experience
You are a subject matter expert in mass spectrometry, especially in the development and validation of PK assays for both small molecules and proteins
Excellent organisational skills and a can-do attitude
You bring extensive experience in protein mass spectrometry (whole protein MS, native MS, peptide mapping), including data analysis
Excellent interpersonal skills
A proven ability to achieve results through others

Desirable requirements Having had previous line management experience would be a distinct benefit in this role
Demonstrate good knowledge and understanding of organic- and protein-chemistry
Expertise in one or more of the following areas, especially applied to antibodies or ADCs This includes ADME/PK assay development, especially for Biologics, Protein characterisation by MS, or Sample enrichment/preparation from biological matrices
Additional experience in a range of analytical techniques for characterisation of proteins (eg HPLC (SEC, HIC, IEX), cIEF, SDS-PAGE, ELISA, SPR, ITC etc)

Does this look like you Next Steps Apply Today

To be considered for this exciting opening, please complete the full application on our website at your earliest convenience It is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity If you know someone who could be a good fit, please share this posting with them

AstraZeneca is an equal opportunity employer AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, gender orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law

Head of Analytical, Spirogen

MedImmune

Profile Summary:

Employment Type : Full Time
Eligibility : Any Graduate
Industry : Biotechnology/Pharmaceutical/Medicine, Manufacturing/Industrial
Functional Area : Bio Tech/R&D/Scientist
Role : Bio-Technology Research
Salary : 200000-400000 P/A
Deadline : 13th Oct 2019

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