Vancomycin and Drug-Drug Interactions - Pharmacology

Vancomycin has adverse reactions when used with some medications. You must wait several hours before giving vancomycin to a patient who has received oral cholestyramine (Questran) or colestipol (Colestid) because these medications lower the therapeutic effect of vancomycin.

Also avoid giving vancomycin if the patient has taken any aminoglycosides because they increase the potential for ototoxicity (ear) and nephrotoxicity (kidney). If the patient receives vancomycin and aminoglycosides, then you must closely monitor vancomycin serum levels to determine that it remains within the safe range. Drug-drug interaction may occur if administering Vancomycin with:

  • Amphotericin B
  • Aspirin
  • Bacitracin
  • Parenteral bumetanide [Bumex]
  • Capreomycin [Capastat]
  • Cisplatin [Platinol]
  • Cyclosporine [Sandimmune]
  • Ethacrynate parenteral [Edecrin]
  • Furosemide parenteral [Lasix]
  • Paromomycin [Humatin]
  • Polymyxins
  • Streptozocin [Zanosar]

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