Tetracyclines and Drug-Drug Interactions - Pharmacology

Tetracyclines can interact with other medications. Avoid giving tetracyclines two hours before or after the patient receives colestipol (Colestid) or cholestyramine (Questran) because these medications decrease the absorption of tetracycline.

Give tetracycline 1-3 hours before or after giving the patient antacids, calcium supplements, choline and magnesium salicylates, iron supplements, magnesium salicylate, or magnesium laxatives, foods containing milk and milk products. These lower the absorption of tetracycline.

Don’t give tetracycline if the patient is taking estrogen-containing oral con¬traceptives since this reduces the contraceptive effectiveness and may result in breakthrough bleeding. Female patients should be advised to use alternative methods of birth control while on antibiotics.

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