Clindamycins and Drug-Drug Interactions - Pharmacology

Besides being associated with pseudo membranous colitis, clindamycin can also cause an adverse interaction with antidiarrheals, chloramphenicol (Chloromycetin), and erythromycin.

Clindamycin is known to enhance the neuromuscular blockage caused by anesthetic agents. This might result in the patient experiencing skeletal muscle weakness, respiratory depression, and even paralysis if used during or immediately after surgery.


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