Chloramphenicol and Drug-Drug Interactions - Pharmacology

Chloramphenicol can have an adverse interaction with alfentanil (Alfenta) by increasing alfentanil levels in the patient. Chloramphenicol is known to increase bone marrow depression when given with anticonvulsants.

Patients who are taking antidiabetic medication may see an increase in the level of that medication when taken with chloramphenicol resulting in hypoglycemia .Therefore, diabetics who take chloramphenicol must closely monitor their blood glucose level.

Chloramphenicol also causes a decrease in the therapeutic effect of clindamycin, erythromycin, or lincomycin. Chloramphenicol increases the drug serum levels of phenobarbital (Luminal), phenytoin (Dilantin), or warfarin (Coumadin) which can lead to toxicity.


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