Aminoglycosides and Drug-Drug Interactions - Pharmacology

Amino glycosides can have undesirable interactions with other medications. When taken with other amino glycosides or capremycin (Capastat) the patient has an increased potential for hearing, kidney, and neuromuscular problems. Hearing loss can lead to total deafness long after the patient stops treatment with amino glycosides.

Neuromuscular blockage may increase when amino glycosides are given to patients who have received anesthetics (halogenated hydrocarbon) or citrate-anticoagulated blood through massive transfusions. Methoxyflurane (Penthrane) and polymyxins, given parenterally also increase the possibility for neuromuscular blockage as well as kidney toxicity.

Aminoglycosides Interactions with Other Drugs

In addition, patients who are treated with aminoglycides can have interactions with the following medications:

  • Amphotericin B parenteral (Fungizone)
  • Aspirin
  • Bacitracin parenteral
  • Bumetanide parenteral aspirin
  • Bacitracin
  • Parenteral bumetanide (Bumex)
  • Cephalothin (Keflin)
  • Cisplatin (Platinol)
  • Cyclosporine (Sandimmune)
  • Ethacrynate parenteral (Edecrin)
  • Furosemide parenteral (Lasix)
  • Paromomycin (Humatin)
  • Polymyxins
  • Streptozocin (Zanosar)
  • Vancomycin (Cancocin)

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